Synthesis and antiviral properties of novel analogues of monophosphate anddiphosphate bioactive forms of acyclovir

New analogues (compounds 6, 7 and 9) of the mono- (8) and diphosphate (10) bioactive forms of the antiherpes drug acyclovir are described. In compound 6, the monophosphate moiety of 8 was replaced by an aminosulfonyloxy group , while in compounds 7 and 9, a phosphonoacetamidoxy and an O-ethyl phospho noacetamidoxy moiety are, respectively present instead of the diphosphate o ne of 10. None of the compounds synthesized proved to possess an appreciabl e activity on herpes simplex virus (HSV) or human immunodeficiency virus (H IV). (C) 2000 Elsevier Science S.A. All rights reserved.