Dihydrofolate reductase activity in the erythroblasts of patients with 5q-syndrome

Authors
Nano, R Invernizzi, R Pecci, A Civallero, M Gerzeli, G
Citation
R. Nano et al., Dihydrofolate reductase activity in the erythroblasts of patients with 5q-syndrome, HAEMATOLOG, 85(7), 2000, pp. 765-766
Citations number
8
Categorie Soggetti
Cardiovascular & Hematology Research
Journal title
HAEMATOLOGICA
ISSN journal
03906078 → ACNP
Volume
85
Issue
7
Year of publication
2000
Pages
765 - 766
Database
ISI
SICI code
0390-6078(200007)85:7<765:DRAITE>2.0.ZU;2-F
Abstract
We demonstrated a qualitative and quantitative cytochemical decrease of dih ydrofolate reductase activity in the erythroblasts of 4 patients with the 5 q- syndrome compared with 10 normal controls and 8 patients with myelodyspl astic diseases. We hypothesized that this enzyme abnormality could be impor tant for understanding the pathogenesis of the syndrome.