Nonimmune interaction of the SfbI protein of Streptococcus pyogenes with the immunoglobulin G F(ab ')(2) fragment

Authors
Medina, E Schulze, K Chhatwal, GS Guzman, CA
Citation
E. Medina et al., Nonimmune interaction of the SfbI protein of Streptococcus pyogenes with the immunoglobulin G F(ab ')(2) fragment, INFEC IMMUN, 68(8), 2000, pp. 4786-4788
Citations number
15
Categorie Soggetti
Immunology
Journal title
INFECTION AND IMMUNITY
ISSN journal
00199567 → ACNP
Volume
68
Issue
8
Year of publication
2000
Pages
4786 - 4788
Database
ISI
SICI code
0019-9567(200008)68:8<4786:NIOTSP>2.0.ZU;2-#
Abstract
Fibronectin-binding protein I (SfbI) of Streptococcus pyogenes binds to mou se immunoglobulin G (IgG) but not to IgA or IgM in a nonimmune fashion. The fibronectin-binding domains of SfbI were responsible for this activity, wh ich was targeted to the IgG F(ab')(2) fragment. SfbI also binds to B cells but not to CD4(+) or CD8(+) lymphocytes.