Role of Nramp1 deletion in Chlamydia infection in mice

Elicited macrophages from 129sv mice with a functional deletion of the natu ral-resistance-associated macrophage protein 1 gene (Nramp1) were shown to be as susceptible as wild-type mice to infection with the Chlamydia trachom atis mouse pneumonitis and L3 serovars and to Chlamydia pneumoniae. Further more, the two groups of mice were shown to be similarly susceptible to an i ntranasal infection with these microorganisms. In conclusion, the Nramp1 ge ne does not appear to play a major role in the regulation of the susceptibi lity of mice to a chlamydial infection.