Elicited macrophages from 129sv mice with a functional deletion of the natu
ral-resistance-associated macrophage protein 1 gene (Nramp1) were shown to
be as susceptible as wild-type mice to infection with the Chlamydia trachom
atis mouse pneumonitis and L3 serovars and to Chlamydia pneumoniae. Further
more, the two groups of mice were shown to be similarly susceptible to an i
ntranasal infection with these microorganisms. In conclusion, the Nramp1 ge
ne does not appear to play a major role in the regulation of the susceptibi
lity of mice to a chlamydial infection.