M. Sznitowska et al., Increased partitioning of pilocarpine to the oily phase of submicron emulsion does not result in improved ocular bioavailability, INT J PHARM, 202(1-2), 2000, pp. 161-164
Submicron emulsions containing pilocarpine as ion-pair with mono-dodecylpho
sphoric acid were prepared. Physical stability of these preparations was co
nfirmed during 4 months of storage at 4 degrees C. Approximately 50% of the
drug was found in the aqueous phase of emulsion separated using an ultrafi
ltration technique, while the rest was present in the oily phase and interp
hase. The miotic effect observed in rabbits after application of the ion-pa
ir in aqueous solution ol in submicron emulsion was the same; indicating th
at the drug distribution into the oily phase of the colloidal vehicle does
not improve ocular bioavailability. (C) 2000 Elsevier Science B.V. All righ
ts reserved.