Salpingectomy for repeated embryo nonimplantation after in vitro fertilization in patients with severe tubal factor infertility

Purpose: To evaluate the impact of salpingectomy on the rates of embryo imp lantation and pregnancy in patients with severe, irreversible tubal factor sterility. Methods: A retrospective study of patients with repeated failure of in vitr o fertilization due to nonimplantation of the embryo. Seventy-two patients with severe and irreversible tubal factor sterility were selected following repeated failure of in vitro fertilization (IVF) due to assumed nonimplant ation of the embryo: 35 underwent a salpingectomy before continuing IVF cyc les and 37 continued IVF cycles without salpingectomy. Results: After the first IVF cycle consecutive to diagnosis of embryo nonim plantation, the implantation rate was 10.2% in the salpingectomy group and 6.1% in the group without the procedure (P = 0.5). After all NF cycles, the rate was, respectively, 6.9% and 4.5% (P = 0.2). Salpingectomy improved th e pregnancy rate (PR) per transfer (23.5% vs. 9.9 %; P = 0.01). The curves of the cumulative probability of becoming pregnant show that salpingectomy resulted in pregnancy more rapidly. Conclusions: Salpingectomy improves the PR per transfer in patients with se vere and irreversible tubal factor sterility who have experienced repented failure of IVF due to embryo nonimplantation, This procedure also reduces t he number of IVF attempts needed to obtain pregnancy.