Study of DNA interactions with melphalan, busulphan, and analogues using an HPLC method

Authors
Karikas, A Constantinou-Kokotou, V Magrioti, V Kokotos, G
Citation
A. Karikas et al., Study of DNA interactions with melphalan, busulphan, and analogues using an HPLC method, J LIQ CHR R, 23(12), 2000, pp. 1859-1864
Citations number
14
Categorie Soggetti
Chemistry & Analysis","Spectroscopy /Instrumentation/Analytical Sciences
Journal title
JOURNAL OF LIQUID CHROMATOGRAPHY & RELATED TECHNOLOGIES
ISSN journal
10826076 → ACNP
Volume
23
Issue
12
Year of publication
2000
Pages
1859 - 1864
Database
ISI
SICI code
1082-6076(2000)23:12<1859:SODIWM>2.0.ZU;2-I
Abstract
A simple reversed phase HPLC method suitable to study the interactions of a lkylating agents with DNA is presented in this paper. DNA interaction is ex pressed as the % DNA peak size exclusion. The effects caused by the antitum or drugs melphalan, busulphan, and busulpan analogues on DNA were clearly o bserved through chromatographic data. The synthetic dimethanesulphonates of 2-tetradecyl-1,4-butanediol and 1,2-hexadecanediol were proved more potent than busulphan.