Spectrophotometric studies and application of imipramine-eriochrome cyanine R system for determination of imipramine in pharmaceuticals

Authors
Starczewska, B
Citation
B. Starczewska, Spectrophotometric studies and application of imipramine-eriochrome cyanine R system for determination of imipramine in pharmaceuticals, J PHARM B, 23(2-3), 2000, pp. 383-386
Citations number
18
Categorie Soggetti
Chemistry & Analysis
Journal title
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
ISSN journal
07317085 → ACNP
Volume
23
Issue
2-3
Year of publication
2000
Pages
383 - 386
Database
ISI
SICI code
0731-7085(20000815)23:2-3<383:SSAAOI>2.0.ZU;2-8
Abstract
Eriochrome cyanine R (ECR) has been tested as reagent for the determination of imipramine. it reacts in neutral medium with imipramine forming reddish compound, which can be quantitatively extracted into n-butanol. This prope rty has been successfully used for the extractive-spectrophotometric determ ination of imipramine. Beer's law is obeyed in concentration range of 10-80 mu g: ml(-1) of imipramine. The method was applied to the determination of imipramine in its pharmaceutical. (C) 2000 Elsevier Science B.V. All right s reserved.