Determination of the lipophilicity of some carbonyl derivatives of 2-aminoimidazolines-2 by reversed-phase thin-layer chromatography. part 2. The lipophilicity of 1,6-diaryl-5,7(1H)dioxo-2,3-dihydroimidazo[1,2-a][1,3,5]triazines and 1-aryl-5,6(1H) dioxo-2,3-dihydroimidazo[1,2-a] imidazoles

The lipophilicity of twenty five new carbonyl derivatives of 1-aryl-2-amino imidazolines-2 (twenty 1,6-diaryl-5,7(1H)dioxo-2,3-dihydroimidazo[1,2-a] [1 ,3,5]triazines and five 1-aryl-5,6(1H)dioxo-2,3- dihydroimidazo[1,2-a] imid azoles) has been determined by RPTLC on commercial RP-18 silica gel plates with methanol-acetic acid-water as mobile phase. R-M values for all the com pounds mere linearly dependent on mobile phase methanol concentration with in the range 60 to 90%. Experimental lipophilicity was determined by use of the calibration curve obtained for six standards and partition coefficient s (as logP) of all the compounds were calculated by means of two different software packages ChemPlus (Hyper-Chem) and SciLogP (Alchemy 2000). The val ues calculated with the SciLogP package correlated very well (r > 0.95) wit h the log P-TLC values; correlation was good (r > 0.8) for values calculate d by use of the ChemPlus package. This suggests that both methodologies are suitable for calculation of the lipophilicity of dioxo derivatives of 2-am inoimidazoline.