H107, a new aminoglycoside anti-Pseudomonas antibiotic produced by a new strain of Spirillospora

Spirillospora spp..(strain 719) has been the source of several antibiotics. One of these designated H107 is produced as a trace. Compared with other a ntibiotics produced by the same strain, it was obtained only from the broth filtrate after precipitation with acetic acid followed by extraction with n-butanol, it was a water soluble metabolite active against Gram-negative b acteria and especially Pseudomonas spp., and was identified as an aminoglyc oside compound. This is the first report of aminoglycoside anti-Pseudomonas production by Spirillospora.