Identification and cloning of a gamma 3 subunit splice variant of the human GABA(A) receptor

Authors
Poulsen, CF Christjansen, KN Hastrup, S Hartvig, L
Citation
Cf. Poulsen et al., Identification and cloning of a gamma 3 subunit splice variant of the human GABA(A) receptor, MOL BRAIN R, 78(1-2), 2000, pp. 201-203
Citations number
6
Categorie Soggetti
Neurosciences & Behavoir
Journal title
MOLECULAR BRAIN RESEARCH
ISSN journal
0169328X → ACNP
Volume
78
Issue
1-2
Year of publication
2000
Pages
201 - 203
Database
ISI
SICI code
0169-328X(20000531)78:1-2<201:IACOAG>2.0.ZU;2-C
Abstract
cDNA sequences encoding two forms of the GABA(A) gamma 3 receptor subunit w ere cloned from human hippocampus. The nucleotide sequences differ by the a bsence (gamma 3S) or presence (gamma 3L) of 18 bp located in the presumed i ntracellular loop between transmembrane region (TM) III and IV. The extra 1 8 bp in the gamma 3L subunit generates a consensus site for phosphorylation by protein kinase C (PKC). Analysis of human genomic DNA encoding the gamm a 3 subunit reveals that the 18 bp insert is contiguous with the upstream p roximal exon. (C) 2000 Elsevier Science B.V. All rights reserved.