Treatment of myasthenia gravis with mycophenolate mofetil: A case report

We report a patient with myasthenia gravis (MG) who had marked clinical ben efit in response to treatment with mycophenolate mofetil as documented by s erial quantitative measures of strength and muscle fatigue. Our patient had experienced either adverse side effects or a suboptimal response to the us ual immunosuppressive agents used in MG. Mycophenolate mofetil was used in combination with cyclosporine and prednisone and allowed for significant re ductions in dosage of these immunosuppressants. We conclude that mycophenol ate mofetil deserves further study as a therapeutic agent in MG. In particu lar, its role as a steroid-sparing agent and as a drug to be used in combin ation immunotherapy in more severe or refractory cases of MG should be inve stigated. (C) 2000 John Wiley & Sons, Inc.