Synthesis of two conformationally constrained analogues of the minor tobacco alkaloid anabasine

[GRAPHICS] The anabasine analogues spiro[4-azaindan-1,2'-piperidine] (7) and spiro[6-a zaindan-1,2'-piperidine] (8) have been prepared. A series of palladium-cata lyzed reactions, where an intramolecular cyclization constituted a key reac tion, were utilized for the preparation of the two target compounds.