Ni(II)/Zn-mediated chemoselective arylation of aromatic aldehydes: Facile synthesis of diaryl carbinols

[GRAPHICS] Direct arylation of aromatic aldehydes with aryl bromides in the presence o f Ni(II)/Zn was investigated. The choice of ligand in this nickel-catalyzed coupling was critical to the formation of the secondary alcohols. Monodent ate phosphine ligands were ineffective, whereas NiBr2- (dppe)/Zn successful ly catalyzed this reductive coupling reaction. The reaction conditions were mild and diarylcarbinols with a variety of functional groups such as keton e, ester, amide, and nitrile groups were readily prepared.