Dynamic kinetic resolution of allylic alcohols mediated by ruthenium- and lipase-based catalysts

Authors
Lee, D Huh, EA Kim, MJ Jung, HM Koh, JH Park, J
Citation
D. Lee et al., Dynamic kinetic resolution of allylic alcohols mediated by ruthenium- and lipase-based catalysts, ORG LETT, 2(15), 2000, pp. 2377-2379
Citations number
22
Categorie Soggetti
Organic Chemistry/Polymer Science
Journal title
ORGANIC LETTERS
ISSN journal
15237060 → ACNP
Volume
2
Issue
15
Year of publication
2000
Pages
2377 - 2379
Database
ISI
SICI code
1523-7060(20000727)2:15<2377:DKROAA>2.0.ZU;2-1
Abstract
[GRAPHICS] An enzyme-metal combo reaction has been developed for the dynamic kinetic r esolution of allylic alcohols in which racemic substrates are transformed b y a lipase and a ruthenium complex in the presence of an acyl donor to ally lic acetates of high optical purity in over 80% yield.