Effects of HAART on the mRNA expression of cell factors involved in drug resistance.

Citation
S. Jorajuria et al., Effects of HAART on the mRNA expression of cell factors involved in drug resistance., PATH BIOL, 48(5), 2000, pp. 490-494
Citations number
19
Categorie Soggetti
Medical Research Diagnosis & Treatment
Journal title
PATHOLOGIE BIOLOGIE
ISSN journal
03698114 → ACNP
Volume
48
Issue
5
Year of publication
2000
Pages
490 - 494
Database
ISI
SICI code
0369-8114(200006)48:5<490:EOHOTM>2.0.ZU;2-F
Abstract
Treatment of the human immunodeficiency virus (HIV) is restricted by therap eutic escape. The biological mechanisms of this chemoresistance rely notabl y on the modulation of cell kinase and P-glycoprotein (P-gp) expression. In this study, we investigated, in cynomolgus macaques, the roles of SHIV89. 6P infection and of HAART in the mRNA expression of these cell factors. SHI V infection, or associated pathophysiological disorders, increase both thym idine kinase and thymidylate kinase mRNA expression and decrease those of P -gp. On the other hand, the expression of other cell kinases is not modulat ed. In parallel, HAART accentuates the decrease of P-gp expression and atte nuates the increase of kinase expression. On the whole, such metabolic diso rders, evidenced herein an animal model of HIV infection, could be involved in HIV-infected patients. (C) 2000 Editions scientifiques et medicales Els evier SAS.