Effect of hydroxypropyl-beta-cyclodextrin on hydrocortisone dissolution from films intended for ocular drug delivery

The formation of an inclusion complex between hydrocortisone and hydroxypro pyl-beta-cyclodextrin can affect the in vitro transfer rate of hydrocortiso ne from the aqueous to the organic phase. The observed first order transfer rate constants showed that the complexation of hydrocortisone with hydroxy propyl-beta-cyclodextrin decreased significantly the transport of the drug depending on the partition coefficient of the drug, and the relative magnit ude of the stability constant of the inclusion complex. To optimize the ocu lar drug delivery, high molecular weight cellulosis and PVA polymeric films were prepared. No unified mathematical model can predict the release profi le of drug and complex from films. The drug and complex-polymer interaction s in each system could be responsible for the solubility of the drug, and d ifferent release behaviours of hydrocortisone and cyclodextrin inclusion co mplex from the films prepared.