Bronchiolitis obliterans organizing pneumonia secondary to chemotheraphy in a child with pericardial sarcoma

The uncommon bronchiolitis obliterans organizing pneumonia can be idiopathi c or caused by infection or medications. We report a 5 year old boy with pe ricardial sarcoma that was treated with chemotherapy (vincristine, doxorubi cin, etoposide, cyclophosphamide) and radiotherapy. During the third cycle of chemotherapy, he developed progressive cough and dyspnea, needing oxygen therapy. Chest X-ray examination showed bilateral infiltrates. After disca rding infectious etiologies, and open lung biopsy was performed, ant the pa thological examination showed a bronchiolitis obliterans organizing pneumon ia. He was treated with prednisolone for 7 days, followed by prednisone for additional 45 days. He continued with fluticasone propionate as maintenanc e and remains in good condition with a chest X-ray showing mild interstitia l images, after seven months of follow up.