A versatile and convenient regioselective acylation of 2 '-deoxynucleosides and ribonucleosides by supported lipases of Pseudomonas Cepacia

Authors
Nair, RV Salunkhe, MM
Citation
Rv. Nair et Mm. Salunkhe, A versatile and convenient regioselective acylation of 2 '-deoxynucleosides and ribonucleosides by supported lipases of Pseudomonas Cepacia, SYN COMMUN, 30(17), 2000, pp. 3115-3120
Citations number
2
Categorie Soggetti
Organic Chemistry/Polymer Science
Journal title
SYNTHETIC COMMUNICATIONS
ISSN journal
00397911 → ACNP
Volume
30
Issue
17
Year of publication
2000
Pages
3115 - 3120
Database
ISI
SICI code
0039-7911(2000)30:17<3115:AVACRA>2.0.ZU;2-1
Abstract
Pseudomonas Cepacia lipase supported on ceramic particles (lipase PS-C) and on diatomite (lipase PS-D)regioselectively acylated 2'-deoxynucleosides an d ribonucleosides to 3'-O-acetyl-2'-deoxynucleosides and 3'-O-acetyl-ribonu cleosides with oxime esters in organic solvents at room temperature. This e nzymatic reaction was significant because the regioselectivity was total; a s any other regioisomer nor the N-acylated product were observed.