The synthesis of a di-nor-secorhazinilam analogue is described. This phenyl
pyrrole compound has been prepared by a Susuki cross-coupling reaction betw
een 1,2,5 trisubstituted pyrrole halides and 2-N-(tertbutoxycarbonyl)aminop
henyl boronic acid. In contrast to rhazinilam, this new phenylpyrrole inhib
its the assembly of tubulin into microtubules. (C) 2000 Elsevier Science Lt
d. All rights reserved.