Synthesis of a rhazinilam analogue acting as an inhibitor of tubulin assembly

Authors
Dupont, C Guenard, D Thal, C Thoret, S Gueritte, F
Citation
C. Dupont et al., Synthesis of a rhazinilam analogue acting as an inhibitor of tubulin assembly, TETRAHEDR L, 41(31), 2000, pp. 5853-5856
Citations number
18
Categorie Soggetti
Chemistry & Analysis","Organic Chemistry/Polymer Science
Journal title
TETRAHEDRON LETTERS
ISSN journal
00404039 → ACNP
Volume
41
Issue
31
Year of publication
2000
Pages
5853 - 5856
Database
ISI
SICI code
0040-4039(20000729)41:31<5853:SOARAA>2.0.ZU;2-J
Abstract
The synthesis of a di-nor-secorhazinilam analogue is described. This phenyl pyrrole compound has been prepared by a Susuki cross-coupling reaction betw een 1,2,5 trisubstituted pyrrole halides and 2-N-(tertbutoxycarbonyl)aminop henyl boronic acid. In contrast to rhazinilam, this new phenylpyrrole inhib its the assembly of tubulin into microtubules. (C) 2000 Elsevier Science Lt d. All rights reserved.