Electrochemical oxidation of 2,2,2-trifluoroethanol to trifluoroacetaldehyde 2,2,2-trifluoroethyl hemiacetal

Citation
K. Shirai et al., Electrochemical oxidation of 2,2,2-trifluoroethanol to trifluoroacetaldehyde 2,2,2-trifluoroethyl hemiacetal, TETRAHEDR L, 41(31), 2000, pp. 5873-5876
Citations number
17
Categorie Soggetti
Chemistry & Analysis","Organic Chemistry/Polymer Science
Journal title
TETRAHEDRON LETTERS
ISSN journal
00404039 → ACNP
Volume
41
Issue
31
Year of publication
2000
Pages
5873 - 5876
Database
ISI
SICI code
0040-4039(20000729)41:31<5873:EOO2TT>2.0.ZU;2-C
Abstract
Electrochemical oxidation of 2,2,2-trifluoroethanol (1) gave trifluoroaceta ldehyde 2,2,2-trifluoroethyl hemiacetal (2b), which was more reactive than commercially available trifluoroacetaldehyde ethyl hemiacetal (2a). The hig h reactivity of 2b was utilized, for example, for the facile synthesis of 1 -furyl-2,2,2-trifluoroethanol (4) from furan. (C) 2000 Elsevier Science Ltd . All rights reserved.