The reaction of dimethyltitanocene with N-substituted-beta-lactams

Authors
Martinez, I Howell, AR
Citation
I. Martinez et Ar. Howell, The reaction of dimethyltitanocene with N-substituted-beta-lactams, TETRAHEDR L, 41(30), 2000, pp. 5607-5611
Citations number
27
Categorie Soggetti
Chemistry & Analysis","Organic Chemistry/Polymer Science
Journal title
TETRAHEDRON LETTERS
ISSN journal
00404039 → ACNP
Volume
41
Issue
30
Year of publication
2000
Pages
5607 - 5611
Database
ISI
SICI code
0040-4039(20000722)41:30<5607:TRODWN>2.0.ZU;2-D
Abstract
2-Methyleneazetidines have been synthesized and isolated by the reaction of beta-lactams with dimethyltitanocene, followed by chromatography on deacti vated silica. Efficient conversion required that the lactam nitrogen be str ongly deactivated. Methyl transfer predominated in reactions with phenyl an d benzyl on the lactam nitrogen. (C) 2000 Elsevier Science Ltd. All rights reserved.