Citation
F. Aznar et al., Enamines in solid-phase: synthesis and reactivity towards electrophiles, TETRAHEDR L, 41(30), 2000, pp. 5683-5687
Citations number
12
Categorie Soggetti
Chemistry & Analysis","Organic Chemistry/Polymer Science
Journal title
TETRAHEDRON LETTERS
ISSN journal
00404039
→ ACNP
Volume
41
Issue
30
Year of publication
2000
Pages
5683 - 5687
Database
ISI
SICI code
0040-4039(20000722)41:30<5683:EISSAR>2.0.ZU;2-X
Abstract
Enamines are synthesized in solid-phase by amination of terminal acetylenes
with a secondary amine attached to Wang resin in a process catalyzed by me
rcury(II) acetate. The enamines obtained react with electrophiles such as i
socyanates and nitroolefins to give rise to the expected addition products,
which can be released from the resin by hydrolysis of the enamine under mi
ld acidic conditions. (C) 2000 Elsevier Science Ltd. All rights reserved.