The undesirable lability of tert-butyldimethylsilyl ethers under Pd/C-catalyzed hydrogenation conditions and solution of the problem by using a Pd/C(en) catalyst

Authors
Hattori, K Sajiki, H Hirota, K
Citation
K. Hattori et al., The undesirable lability of tert-butyldimethylsilyl ethers under Pd/C-catalyzed hydrogenation conditions and solution of the problem by using a Pd/C(en) catalyst, TETRAHEDR L, 41(30), 2000, pp. 5711-5714
Citations number
15
Categorie Soggetti
Chemistry & Analysis","Organic Chemistry/Polymer Science
Journal title
TETRAHEDRON LETTERS
ISSN journal
00404039 → ACNP
Volume
41
Issue
30
Year of publication
2000
Pages
5711 - 5714
Database
ISI
SICI code
0040-4039(20000722)41:30<5711:TULOTE>2.0.ZU;2-6
Abstract
While the frequent and unexpected loss of the TBDMS protective group of a v ariety of hydroxylic functions was demonstrated under neutral and mild hydr ogenation conditions using 10% Pd/C, the undesirable problem was perfectly overcome by using a 10% Pd/C-ethylenediamine complex catalyst. (C) 2000 Els evier Science Ltd. All rights reserved.