Elucidating a biological role for chromium at a molecular level

Chromium is an essential trace element for mammals and is required for main tenance of proper carbohydrate and lipid metabolism. However, elucidating i ts function at a molecular level has proved to be problematic. Recent resea rch has revealed that the chromium-binding oligopeptide chromodulin may pla y a unique role in the autoamplification of insulin signaling. Attempts to develop chromium-containing nutritional supplements and therapeutics are de scribed.