SYNTHESIS AND BIOLOGICAL-ACTIVITY OF A NEW ANTI-FACTOR XA PENTASACCHARIDE WITH A C-INTERGLYCOSIDIC BOND

Authors
HELMBOLDT A PETITOU M MALLET JM HERAULT JP LORMEAU JC DRIGUEZ PA HERBERT JM SINAY P
Citation
A. Helmboldt et al., SYNTHESIS AND BIOLOGICAL-ACTIVITY OF A NEW ANTI-FACTOR XA PENTASACCHARIDE WITH A C-INTERGLYCOSIDIC BOND, Bioorganic & medicinal chemistry letters, 7(12), 1997, pp. 1507-1510
Citations number
37
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
7
Issue
12
Year of publication
1997
Pages
1507 - 1510
Database
ISI
SICI code
0960-894X(1997)7:12<1507:SABOAN>2.0.ZU;2-C
Abstract
A mixed synthetic C, O-pentasaccharide 17 has been synthesized and sho wn to display an anti-factor Xa activity similar to that of the corres ponding O-pentasaccharide 18. 17 represents the first example of a syn thetic C-oligosaccharidic mimetic eliciting a significant biological r esponse. (C) 1997 Elsevier Science Ltd.