SYNTHESIS AND ANTIRHEUMATIC ACTIVITY OF NOVEL TETRAHYDROQUINOLINE-8-CARBOXYLIC ACID-DERIVATIVES

Authors
KOHNO Y AWANO K MIYASHITA M FUJIMORI S KURIYAMA K SAKOE Y KUDOH S SAITO K KOJIMA E
Citation
Y. Kohno et al., SYNTHESIS AND ANTIRHEUMATIC ACTIVITY OF NOVEL TETRAHYDROQUINOLINE-8-CARBOXYLIC ACID-DERIVATIVES, Bioorganic & medicinal chemistry letters, 7(12), 1997, pp. 1515-1518
Citations number
9
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
7
Issue
12
Year of publication
1997
Pages
1515 - 1518
Database
ISI
SICI code
0960-894X(1997)7:12<1515:SAAAON>2.0.ZU;2-3
Abstract
A study of the modification of N-alkylanthranilic acids to develop nov el DMARDs is detailed. 1,2,3,4-Tetrahydroquinoline-8-carboxylic acid d erivatives were found to exhibit a therapeutic effect on adjuvant arth ritis and a suppressive effect on bone destruction. (C) 1997 Elsevier Science Ltd.