STEREOSELECTIVE SYNTHESIS OF NEO-C-GLYCOPEPTIDE BUILDING-BLOCKS - TOWARDS A FLEXIBLE AND CONTROL-ORIENTED DESIGN AS PROBES FOR CARBOHYDRATE-PROTEIN INTERACTIONS

Authors
ARYA P DION S SHIMIZU GKH
Citation
P. Arya et al., STEREOSELECTIVE SYNTHESIS OF NEO-C-GLYCOPEPTIDE BUILDING-BLOCKS - TOWARDS A FLEXIBLE AND CONTROL-ORIENTED DESIGN AS PROBES FOR CARBOHYDRATE-PROTEIN INTERACTIONS, Bioorganic & medicinal chemistry letters, 7(12), 1997, pp. 1537-1542
Citations number
47
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
7
Issue
12
Year of publication
1997
Pages
1537 - 1542
Database
ISI
SICI code
0960-894X(1997)7:12<1537:SSONB->2.0.ZU;2-A
Abstract
Neo-C-glycopeptides (1-4) have been synthesized as building blocks to obtain higher neo-C-glycopeptides as probes for studying carbohydrate- protein interactions. A convergent approach for the synthesis of 4 has been developed, in which two galactose units are attached to a glycin e derivative in a stepwise procedure (reductive amination followed by amide coupling) and finally coupling to the protected dipeptide having a free amino group on the side chain. (C) 1997 Elsevier Science Ltd.