DESIGN AND SYNTHESIS OF A NOVEL CLASS OF THROMBIN INHIBITORS INCORPORATING HETEROCYCLIC DIPEPTIDE SURROGATES

Authors
TAMURA SY SEMPLE JE REINER JE GOLDMAN EA BRUNCK TK LIMWILBY MS CARPENTER SH ROTE WE OLDESHULTE GL RICHARD BM NUTT RF RIPKA WC
Citation
Sy. Tamura et al., DESIGN AND SYNTHESIS OF A NOVEL CLASS OF THROMBIN INHIBITORS INCORPORATING HETEROCYCLIC DIPEPTIDE SURROGATES, Bioorganic & medicinal chemistry letters, 7(12), 1997, pp. 1543-1548
Citations number
33
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
7
Issue
12
Year of publication
1997
Pages
1543 - 1548
Database
ISI
SICI code
0960-894X(1997)7:12<1543:DASOAN>2.0.ZU;2-2
Abstract
Several potent and selective inhibitors of thrombin incorporating nove l heterocyclic peptide surrogates in the P-3-P-2 position of peptidyl argininals have been discovered. Illustrated in this article are three classes of heterocycles: pyridones, uracils, and pyrimidinones. The s ynthesis and biological activities of these unique aromatic heterocycl ic derivatives are reported herein. (C) 1997 Elsevier Science Ltd.