REPLACEMENT OF THE PHOSPHODIESTER LINKAGE IN OLIGONUCLEOTIDES BY HETEROCYCLES - THE EFFECT OF TRIAZOLE-MODIFIED AND IMIDAZOLE-MODIFIED BACKBONES ON DNA RNA DUPLEX STABILITY/

Authors
VONMATT P ALTMANN KH
Citation
P. Vonmatt et Kh. Altmann, REPLACEMENT OF THE PHOSPHODIESTER LINKAGE IN OLIGONUCLEOTIDES BY HETEROCYCLES - THE EFFECT OF TRIAZOLE-MODIFIED AND IMIDAZOLE-MODIFIED BACKBONES ON DNA RNA DUPLEX STABILITY/, Bioorganic & medicinal chemistry letters, 7(12), 1997, pp. 1553-1556
Citations number
12
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
7
Issue
12
Year of publication
1997
Pages
1553 - 1556
Database
ISI
SICI code
0960-894X(1997)7:12<1553:ROTPLI>2.0.ZU;2-H
Abstract
Thymidine dinucleotide analogs with imidazole-derived backbones (III a nd IV) were synthesized. These modified dimeric building blocks were i ncorporated into oligodeoxyribonucleotides. The hybridization affinity of the modified oligonucleotides for RNA complements was determined a nd compared to the corresponding olefinic modifications I and II. (C) 1997 Elsevier Science Ltd.