INHIBITION OF CARBOXYPEPTIDASE A BY N-(4-T-BUTYLBENZOYL)-2-HYDROXY-1-NAPHTHALDEHYDE HYDRAZONE

Authors
LANTHIER CM PARNIAK MA DMITRIENKO GI
Citation
Cm. Lanthier et al., INHIBITION OF CARBOXYPEPTIDASE A BY N-(4-T-BUTYLBENZOYL)-2-HYDROXY-1-NAPHTHALDEHYDE HYDRAZONE, Bioorganic & medicinal chemistry letters, 7(12), 1997, pp. 1557-1562
Citations number
26
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
7
Issue
12
Year of publication
1997
Pages
1557 - 1562
Database
ISI
SICI code
0960-894X(1997)7:12<1557:IOCABN>2.0.ZU;2-5
Abstract
N-(4-t-Butylbenzoyl)-2-hydroxy-1-naphthaldehyde hydrazone (2), which i s a potent inhibitor of HIV-1 reverse transcriptase, was found to inhi bit carboxypeptidase A in a mixed uncompetitive-competitive mode, Mole cular modeling studies suggest that 2 may inhibit CPA by binding to th e S-1 and S-2 subsites of free CPA as well as to the CPA-phenylalanine binary enzyme-product complex. (C) 1997 Elsevier Science Ltd.