AN EFFICIENT PREPARATION OF THE POTENT AND SELECTIVE PSEUDOPEPTIDE THROMBIN INHIBITOR, INOGATRAN

Authors
PREVILLE P HE JX TARAZI M SIDDIQUI MA CODY WL DOHERTY AM
Citation
P. Preville et al., AN EFFICIENT PREPARATION OF THE POTENT AND SELECTIVE PSEUDOPEPTIDE THROMBIN INHIBITOR, INOGATRAN, Bioorganic & medicinal chemistry letters, 7(12), 1997, pp. 1563-1566
Citations number
15
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
7
Issue
12
Year of publication
1997
Pages
1563 - 1566
Database
ISI
SICI code
0960-894X(1997)7:12<1563:AEPOTP>2.0.ZU;2-2
Abstract
Inogatran is an effective and selective pseudopeptide inhibitor of thr ombin that has been shown to be efficacious in a series of in vitro an d in vivo models of thrombosis. Herein, we report an efficient and con vergent chemical synthesis of Inogatran that is amenable to the prepar ation of multiple gram quantities. (C) 1997 Elsevier Science Ltd.