PROPERTIES OF FLUOROPHORES ON SOLID-PHASE RESINS - IMPLICATIONS FOR SCREENING, ENCODING AND REACTION MONITORING

Authors
SCOTT RH BALASUBRAMANIAN S
Citation
Rh. Scott et S. Balasubramanian, PROPERTIES OF FLUOROPHORES ON SOLID-PHASE RESINS - IMPLICATIONS FOR SCREENING, ENCODING AND REACTION MONITORING, Bioorganic & medicinal chemistry letters, 7(12), 1997, pp. 1567-1572
Citations number
14
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
7
Issue
12
Year of publication
1997
Pages
1567 - 1572
Database
ISI
SICI code
0960-894X(1997)7:12<1567:POFOSR>2.0.ZU;2-W
Abstract
Fluorescent molecules covalently attached to resin beads are analysed to explore the application of on-bead fluorescence in combinatorial ch emistry, and in particular: screening, encoding and reaction monitorin g. The range of linearity of on-bead fluorescence is shown to be depen dent on both the extent of loading and the Stokes shift of the fluorop hore. Spectral deconvolution of multiple fluorophores on-bead is demon strated. (C) 1997 Elsevier Science Ltd.