ADA-BYPASS BY LIPOPHILIC CYCLOSAL-DDAMP PRO-NUCLEOTIDES A 2ND EXAMPLEOF THE EFFICIENCY OF THE CYCLOSAL-CONCEPT

Authors
MEIER C KNISPEL T DECLERCQ E BALZARINI J
Citation
C. Meier et al., ADA-BYPASS BY LIPOPHILIC CYCLOSAL-DDAMP PRO-NUCLEOTIDES A 2ND EXAMPLEOF THE EFFICIENCY OF THE CYCLOSAL-CONCEPT, Bioorganic & medicinal chemistry letters, 7(12), 1997, pp. 1577-1582
Citations number
23
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
7
Issue
12
Year of publication
1997
Pages
1577 - 1582
Database
ISI
SICI code
0960-894X(1997)7:12<1577:ABLCPA>2.0.ZU;2-J
Abstract
The synthesis of lipophilic pro-nucleotides of ddAMP 2 based on cycloS al-ddAMP 3a-c is described. Phosphotriesters 3 released ddAMP 2 select ively by a controlled, chemically induced tandem reaction. CycloSal-ph osphotriesters 3 exhibited antiviral activity against HIV-1/HIV-2 in C EM cells that where by a factor up to hundred higher as compared to dd A 1. (C) 1997 Elsevier Science Ltd.