A 33-year-old patient with cranial epidural tuberculoma without history of
tuberculosis is described. CT and MR imaging showed a lesion located on bot
h sides of a right frontotemporal bone destruction with epidural extent. Ex
cept for a small necrotic core, the lesion enhanced intensely after contras
t medium administration. Osteitis and subgaleal abscess were associated. Th
e displaced dura mater delineated the epidural tuberculoma. Diagnosis was v
erified by histology and identification of Mycobacterium tuberculosis. Afte
r removal of the tuberculoma and combination therapy, there was a complete
regression of abnormalities. Differential diagnoses are dural tuberculoma,
focal tuberculous pachymeningitis and tuberculous epidural empyema.