SCHIZOPHRENIA AND L-745,870, A NOVEL DOPAMINE D4 RECEPTOR ANTAGONIST

The discovery of a novel high-affinity and selective dopamine D4 recep tor antagonist, L-745,870, and the results of clinical trials with thi s compound are reviewed. Despite several lines of evidence which sugge st that a selective D4 receptor antagonist may be an effective antipsy chotic agent with a lower propensity to induce extrapyramidal side-eff ects, L-745,870 was ineffective as an antipsychotic in humans.