The contents of 15 different phenolic compounds in apple leaves and fr
uit skin from various orchards were determined by HPLC. High concentra
tions of flavan-3-ols were found in those orchards which were not infe
cted by Venturia inaequalis. This observation corroborates earlier fin
dings on different cultivars. The hypothesis that these compounds coul
d be involved in the resistance of apple to scab was tested by inhibit
ing the key enzyme of the phenol biosynthesis, the phenylalanine-ammon
ia-lyase, in young shoots of the resistant genotype 'Sir Prize'. After
inoculation of the inhibitor-treated leaves, severe symptoms of the d
isease occurred. The fungal infection was confirmed by histological st
udies. No flavonal-accumulation could be observed at the infection sit
e which was the case in the non-inhibited but inoculated controls.