Serum feline trypsin-like immunoreactivity following administration of ceruletide to healthy cats

Objective - To determine changes in serum feline trypsin-like immunoreactiv ity (fTLI) in response to administration of ceruletide to healthy cats, Animals - 11 healthy cats. Procedures - Serum fTLI was determined, using a radioimmunoassay, before an d 10, 20, 30, 40, and 50 minutes after IM administration of ceruletide (0.3 mg/kg [0.14 mg/lb]). Results - Mean +/- SD baseline serum fTLI was 23.1 +/- 4.1 mg/L. There was a statistically significant, but clinically unimportant, increase in serum fTLI 10 and 30 minutes after ceruletide administration. Conclusions and Clinical Relevance - In healthy cats, administration of cer uletide induced a statistically significant, but clinically unimportant, in crease in serum fTLI. Whether responses in cats with exocrine pancreatic di sorders would be different is unknown, but results suggest that a ceruletid e stimulation test would likely not be useful for differentiating between h ealthy cats and cats with subclinical chronic exocrine pancreatic disorders .