H. Narita et al., Fluorescent molecular recognition for endocrine-disrupting chemicals and their analogs by fluorescent hetero-modified cyclodextrins, ANAL SCI, 16(7), 2000, pp. 701-705
Fluorescent molecular sensing for endocrine-disrupting chemicals and their
analogs has been studied by investigating the fluorescence spectral change
of regio-selective dansyl-tosyl-modified beta and gamma-cyclodextrins upon
the addition of a guest. These host compounds show pure monomer fluorescenc
e at around 526 nm; the intensities of the guest-induced fluorescence eithe
r increase or decrease according to the accommodation of such guests as dio
xin analogs, p-nonylphenol, 2,4-dichlorophenoxyacetic acid, bisphenol A, an
d diethylphthalate. The extent of the fluorescence variations with the gues
t is employed to display the sensing abilities of these hosts. The sensing
parameter, Delta I/I-0, was used to describe the sensing ability of the hos
ts, where I and I-0 are the fluorescence intensities in the presence and ab
sence of a guest and Delta I=I-I-0. These hosts exhibit highly sensitive an
d selective molecular-recognition ability, particularly for 2,4,6-trichloro
phenol and bisphenol A.