Psychosocial stress has been reported to play a role in the onset and/
or exacerbation of alopecia areata. Little is known about the clinical
characteristics of alopecia areata patients whose alopecia is stress-
reactive. We examined the relation between the stress reactivity of al
opecia areata and a wide range of psychosocial measures among 16 patie
nts with alopecia areata/ totalis and 28 patients with alopecia univer
salis. The degree to which the alopecia was exacerbated by stress was
measured by patient ratings on a 10-point scale. A wide range of psych
ologic measures correlated (p<0.05) with the stress reactivity score.
Stepwise logistic regression analysis revealed that patients with high
er depression scores were more likely to be in the high-stress reactor
group. Patients whose alopecia is stress-reactive may suffer from dep
ressive illness, a potentially important consideration in the overall
management of such patients.