S. Seifert et al., Stability studies on (99m)Technetium(III) complexes with tridentate/monodentate thiol ligands and phosphine ('3+1+1' complexes), APPL RAD IS, 53(3), 2000, pp. 431-438
The preparation and characterisation of 3+1+1 technetium complexes of the g
eneral formula [Tc(SES)(RS)(PMe2Ph)] (SES = tridentate dithiol ligand, E =
S, O, NMe; RSH = monothiol ligand) at the n.c.a. level is described. The Tc
(III) complexes are prepared in a one-step procedure starting from pertechn
etate in yields of 85-95% of radiochemical purity. A comparison of their ch
romatographic data with the fully characterised Tc-99 complexes indicate th
e identity of the investigated compounds. Stability studies show that the T
c-99m complexes undergo some alteration in solution. They are oxidised to t
he 3+1 oxotechnetium (V) complexes and/or decompose in aqueous solution. In
challenge experiments performed with glutathione, exchange of the monothio
lato ligand occurs in the same manner as known for the 3+1 complexes. (C) 2
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