Renin angiotensin aldosterone system and drug allergies complicated with hypotension

Citation
M. Karaayvaz et al., Renin angiotensin aldosterone system and drug allergies complicated with hypotension, A P J ALLER, 18(2), 2000, pp. 81-83
Citations number
7
Categorie Soggetti
Clinical Immunolgy & Infectious Disease
Journal title
ASIAN PACIFIC JOURNAL OF ALLERGY AND IMMUNOLOGY
ISSN journal
0125877X → ACNP
Volume
18
Issue
2
Year of publication
2000
Pages
81 - 83
Database
ISI
SICI code
0125-877X(200006)18:2<81:RAASAD>2.0.ZU;2-I
Abstract
It has been discussed in several studies that non-immunologic factors, such as renin angiotensin aldosterone system (RAAS) may play a role in the path ophysiology of anaphylaxis. This study aimed to determine whether RAAS play s a part in the fall in blood pressure during drug reactions or not. Twenty patients who experienced hypotension during drug reaction and 15 healthy v olunteers were enrolled in this study. None of the patients in the study or control groups were under treatment with any drug that was capable of infl uencing to RAAS. Serum levels of angiotensin-l (A-l), angiotensin-ll (A-ll) , angiotensin converting enzyme (ACE) and aldosterone were measured in both study and control groups. The Mann-Whitney U test was used to compare the results of the groups. There were no statistically significant differences between the groups with respect to A-I, A-ii, ACE and aldosterone levels. I t was concluded that a fall in blood pressure during drug reaction must be the result of mast cell mediator effects on the vascular wall rather than R AAS impairment.