It has been discussed in several studies that non-immunologic factors, such
as renin angiotensin aldosterone system (RAAS) may play a role in the path
ophysiology of anaphylaxis. This study aimed to determine whether RAAS play
s a part in the fall in blood pressure during drug reactions or not. Twenty
patients who experienced hypotension during drug reaction and 15 healthy v
olunteers were enrolled in this study. None of the patients in the study or
control groups were under treatment with any drug that was capable of infl
uencing to RAAS. Serum levels of angiotensin-l (A-l), angiotensin-ll (A-ll)
, angiotensin converting enzyme (ACE) and aldosterone were measured in both
study and control groups. The Mann-Whitney U test was used to compare the
results of the groups. There were no statistically significant differences
between the groups with respect to A-I, A-ii, ACE and aldosterone levels. I
t was concluded that a fall in blood pressure during drug reaction must be
the result of mast cell mediator effects on the vascular wall rather than R
AAS impairment.