M. Kogiso et al., Self-assembled peptide fibers from valylvaline bola-amphiphiles by a parallel beta-sheet network, BBA-GEN SUB, 1475(3), 2000, pp. 346-352
A series of dipeptide-based bola-amphiphiles, bis(N-alpha-amide-L-valyl-L-v
aline) 1, n-alkane dicarboxylate (n = 4-12), have been synthesized. The bol
a-amphiphiles with n = 4 and 6 self-assembled to form crystalline solids in
water, whereas those with n = 7-12 produced peptide fibers. FT-IR spectros
copy and X-ray diffraction patterns revealed that the peptide fibers have p
arallel-type beta-sheet networks between the valylvaline units. FT-IR decon
volution study of carboxyl regions indicated that these crystalline solids
and peptide fibers are stabilized by interlayer bifurcated and intralayer l
ateral hydrogen-bond networks between the end carboxylic acid groups, respe
ctively. (C) 2000 Elsevier Science B.V. All rights reserved.