Respiratory failure during induction chemotherapy for acute myelomonocyticleukaemia (FAB M4Eo) with Ara-C and all-trans retinoic acid

Authors
Lester, WA Hull, DR Fegan, CD Morris, TCM
Citation
Wa. Lester et al., Respiratory failure during induction chemotherapy for acute myelomonocyticleukaemia (FAB M4Eo) with Ara-C and all-trans retinoic acid, BR J HAEM, 109(4), 2000, pp. 847-850
Citations number
12
Categorie Soggetti
Hematology,"Cardiovascular & Hematology Research
Journal title
BRITISH JOURNAL OF HAEMATOLOGY
ISSN journal
00071048 → ACNP
Volume
109
Issue
4
Year of publication
2000
Pages
847 - 850
Database
ISI
SICI code
0007-1048(200006)109:4<847:RFDICF>2.0.ZU;2-4
Abstract
We report two cases of acute myeloid leukaemia FAB classification M4Eo with high white cell counts at presentation, who developed acute respiratory fa ilure with pulmonary infiltrates on chest radiograph soon after commencing conventional cytotoxic chemotherapy plus all-trans retinoic acid (ATRA). We suggest that in patients with M4Eo ATRA should be used with caution, perha ps delaying its commencement until the white cell count is < 10 x 10(9)/l.