Synthesis and biological studies of glycosyl dopamine derivatives as potential antiparkinsonian agents

Authors
Fernandez, C Nieto, O Rivas, E Montenegro, G Fontenla, JA Fernandez-Mayoralas, A
Citation
C. Fernandez et al., Synthesis and biological studies of glycosyl dopamine derivatives as potential antiparkinsonian agents, CARBOHY RES, 327(4), 2000, pp. 353-365
Citations number
18
Categorie Soggetti
Agricultural Chemistry","Chemistry & Analysis","Organic Chemistry/Polymer Science
Journal title
CARBOHYDRATE RESEARCH
ISSN journal
00086215 → ACNP
Volume
327
Issue
4
Year of publication
2000
Pages
353 - 365
Database
ISI
SICI code
0008-6215(20000807)327:4<353:SABSOG>2.0.ZU;2-3
Abstract
A new approach to deliver dopamine into the central nervous system, based o n the use of D-glucose as transportable agent, has been studied. Glycosyl d opamine derivatives bearing the sugar moiety linked to either the amino gro up or the catechol ring of dopamine through amide, eater or glycosidic bond s were synthesised as potential antiparkinsonian agents. Studies on the bin ding to dopamine D-2 receptor, in vitro stability, and locomotive effect in mice of the synthetic glycoconjugates are reported. (C) 2000 Elsevier Scie nce Ltd. All rights reserved.