Asymmetric synthesis of indolizidine alkaloids by ring-closing-ring-opening metathesis

Authors
Ovaa, H Stragies, R van der Marel, GA van Boom, JH Blechert, S
Citation
H. Ovaa et al., Asymmetric synthesis of indolizidine alkaloids by ring-closing-ring-opening metathesis, CHEM COMMUN, (16), 2000, pp. 1501-1502
Citations number
12
Categorie Soggetti
Chemistry
Journal title
CHEMICAL COMMUNICATIONS
ISSN journal
13597345 → ACNP
Issue
16
Year of publication
2000
Pages
1501 - 1502
Database
ISI
SICI code
1359-7345(2000):16<1501:ASOIAB>2.0.ZU;2-V
Abstract
Asymmetric Pd(0) catalyzed allylic amination followed by a Ru catalyzed RCM -ROM sequence converted an easily accessible racemic cyclopentenol 2 to the functionalized tetrahydropyridine 9 which can be used for the asymmetrical synthesis of indolizidine 13.