The first synthesis of both enantiomers of [alpha-H-2]phenylacetic acid inhigh enantiomeric excess

Authors
Matoishi, K Hanzawa, S Kakidani, H Suzuki, M Sugai, T Ohta, H
Citation
K. Matoishi et al., The first synthesis of both enantiomers of [alpha-H-2]phenylacetic acid inhigh enantiomeric excess, CHEM COMMUN, (16), 2000, pp. 1519-1520
Citations number
8
Categorie Soggetti
Chemistry
Journal title
CHEMICAL COMMUNICATIONS
ISSN journal
13597345 → ACNP
Issue
16
Year of publication
2000
Pages
1519 - 1520
Database
ISI
SICI code
1359-7345(2000):16<1519:TFSOBE>2.0.ZU;2-8
Abstract
Arylmalonate decarboxylase (EC. 4. 1. 1. 76) catalysed decarboxylation foll owed by enantioface-differentiating protonation of [alpha-H-2]- and [alpha- H-1]phenylmalonic acid in (H2O)-H-1 and (H2O)-H-2 respectively, gave highly enantiomerically enriched (R)- and (S)-[alpha-H-2]phenylacetic acid in qua ntitative yields.