Chemistry of substituted quinolinones I. Synthesis of novel triazinylmethylquinolinone derivatives

Functionalization of 1H-quinolin-2-one moiety, at the position 3, with pyru vic or 2-thiopyruvic acid substrates, in order to develop novel synthons of heterocyclic derivatives of quinolinone, was achieved through ring-closure and ring-opening routes. The syntheses of some new 3-([1,2,4]triazin-6-ylm ethyl) quinolines have been described. Three multiaza-polynuclear heterocyc les, viz. triazinophthalazine, triazinoindole, and bistriazinoquinoxaline, were also synthesized and are expected Go have biological importance. The s tructures of all new products were verified on the basis of their elemental and spectral analyses.