LINOLEYL HYDROXAMATE AS 5-LIPOXYGENASE INHIBITOR

The ability of linoleyl hydroxamate to inhibit 5-lipoxygenase from pot ato tubers has been studied. The compound inhibited the activity of th e enzyme at concentrations as low as 10(-7) M. The effect was dose- an d pH-dependent, and showed some relationship to the concentration of t he substrate (linoleate). The extent of enzyme inhibition was not dete rmined by the time of preincubation with linoleyl hydroxamate. The inh ibitor was not oxidized by 5-lipoxygenase under aerobiosis.