LINOLEYL HYDROXAMATE AS 5-LIPOXYGENASE INHIBITOR

Citation
Ia. Butovich et al., LINOLEYL HYDROXAMATE AS 5-LIPOXYGENASE INHIBITOR, Biochemistry, 59(6), 1994, pp. 597-600
Citations number
9
Categorie Soggetti
Biology
Journal title
ISSN journal
00062979
Volume
59
Issue
6
Year of publication
1994
Pages
597 - 600
Database
ISI
SICI code
0006-2979(1994)59:6<597:LHA5I>2.0.ZU;2-I
Abstract
The ability of linoleyl hydroxamate to inhibit 5-lipoxygenase from pot ato tubers has been studied. The compound inhibited the activity of th e enzyme at concentrations as low as 10(-7) M. The effect was dose- an d pH-dependent, and showed some relationship to the concentration of t he substrate (linoleate). The extent of enzyme inhibition was not dete rmined by the time of preincubation with linoleyl hydroxamate. The inh ibitor was not oxidized by 5-lipoxygenase under aerobiosis.