H. Takahashi et al., HIGHER PREVALENCE OF BORNA-DISEASE-VIRUS INFECTION IN BLOOD-DONORS LIVING NEAR THOROUGHBRED HORSE FARMS, Journal of medical virology, 52(3), 1997, pp. 330-335
It is believed that Borna disease virus (BDV), an etiological agent of
progressive polioencephalomyelitis in horses and sheep, is closely as
sociated with psychiatric disorders in humans since the prevalence of
BDV is higher in psychiatric patients than in blood donors. We investi
gated whether or not BDVs in humans are derived from infected domestic
animals, by characterizing the BDVs in blood donors and horses derive
d from the same region of Hokkaido island, Japan. The seroprevalences
(2.6 to 14.8%) of BDV were significantly higher in the blood donors fr
om four regions where most horse farms are concentrated, compared with
only 1% in the blood donors from Sapporo, the largest city in Hokkaid
o. BDV RNA was also detected in peripheral blood mononuclear cells fro
m most of the seropositive horses and blood donors by nested reverse t
ranscriptase-polymerase chain reaction. These findings support that BD
V may be horizontally transmitted, at least in part, from infected hor
ses to humans. (C) 1997 Wiley-Liss, Inc.